[HTML][HTML] The Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and-200, are required for the development of the olfactory and GnRH system
G Garaffo, D Conte, P Provero, D Tomaiuolo… - Molecular and Cellular …, 2015 - Elsevier
During neuronal development and maturation, microRNAs (miRs) play diverse functions
ranging from early patterning, proliferation and commitment to differentiation, survival,
homeostasis, activity and plasticity of more mature and adult neurons. The role of miRs in
the differentiation of olfactory receptor neurons (ORNs) is emerging from the conditional
inactivation of Dicer in immature ORN, and the depletion of all mature miRs in this system.
Here, we identify specific miRs involved in olfactory development, by focusing on mice null …
ranging from early patterning, proliferation and commitment to differentiation, survival,
homeostasis, activity and plasticity of more mature and adult neurons. The role of miRs in
the differentiation of olfactory receptor neurons (ORNs) is emerging from the conditional
inactivation of Dicer in immature ORN, and the depletion of all mature miRs in this system.
Here, we identify specific miRs involved in olfactory development, by focusing on mice null …
