[HTML][HTML] CD11c+ monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23
In inflammatory bowel diseases, a breakdown in host microbial interactions accompanies
sustained activation of immune cells in the gut. Functional studies suggest a key role for
interleukin-23 (IL-23) in orchestrating intestinal inflammation. IL-23 can be produced by
various mononuclear phagocytes (MNPs) following acute microbial stimulation, but little is
known about the key cellular sources of IL-23 that drive chronic intestinal inflammation. Here
we have addressed this question using a physiological model of bacteria-driven colitis. By …
sustained activation of immune cells in the gut. Functional studies suggest a key role for
interleukin-23 (IL-23) in orchestrating intestinal inflammation. IL-23 can be produced by
various mononuclear phagocytes (MNPs) following acute microbial stimulation, but little is
known about the key cellular sources of IL-23 that drive chronic intestinal inflammation. Here
we have addressed this question using a physiological model of bacteria-driven colitis. By …